GDC-0276

SKU: orb1709628

Description

GDC-0276 is a potent and selective oral inhibitor of the voltage-gated sodium channel NaV1.7. It serves as a valuable research tool for investigating pain pathways and has demonstrated efficacy in preclinical models of neuropathic and inflammatory pain.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1494581-70-2
• MW: 462.58
• Purity: 99.77% (May vary between batches)
• Formula: C₂₄H₃₁FN₂O₄S
• SMILES: O=C(NS(=O)(=O)N1CCC1)C=2C=C(C(OCC34CC5CC(CC(C5)C3)C4)=CC2F)C6CC6
• Target: Sodium Channel
• Solubility: 10% DMSO+90% Corn Oil:5 mg/mL (10.81 mM);DMSO:100 mg/mL (216.18 mM)

Bioactivity

• Target IC50:
  NaV1.7 Electrophysiology:0.4 nM
• In Vivo:
  In a mouse model of inherited erythromelalgia (IEM), GDC-0276 treatment showed a concentration-dependent reduction in nociceptive events with an EC50 of 1.7 μM.
• In Vitro:
  GDC-0276 is a potent, selective, reversible, orally active NaV1.7 inhibitor with an IC50 of 0.4 nM and a Ki of 1.1 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GDC0276, GDC-0276, GDC 0276, NaV1.7 Electrophysiology, RG7893, RG-7893

Compound Identifiers

PubChem CID

91809347