Garenoxacin

SKU: orb1225793

Description

A quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.Bacterial Infection Approved.

Key Properties

• CAS Number: 194804-75-6
• MW: 426.4127
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₀F₂N₂O₄
• SMILES: O=C(C1=CN(C2CC2)C3=C(C=CC(C4=CC5=C([C@@H](C)NC5)C=C4)=C3OC(F)F)C1=O)O
• Target: Antibacterial
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Garenoxacin (12.5-50 mg/kg; s. c. ; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumonia infection. Garenoxacin (10 and 30 mg/kg; p.o. ; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice. Animal model: Swiss mice with S. pneumonia infection. Dosage: 12.5, 25 and 50 mg/kg. Administration: Subcutaneous injection, once. Result: Significantly improved the survival rate.
• In Vitro:
  Garenoxacin (BMS284756) (0-8 days) inhibits mycoplasmas and ureaplasmas with MIC90s ≤0.25 μg/mL against tested strains. Garenoxacin (48 h) inhibits S. aureus wild type and mutants with MICs of 0.0128-4.0 μg/mL. Garenoxacin inhibits topoisomerase IV and gyrase from S. aureus with IC50s of 1.25 to 2.5 and 1.25 μg/mL, respectively. Garenoxacin has a low propensity for selective enrichment of fluoroquinolone-resistant mutants among ciprofloxacin-susceptible isolates of S. aureus.: Cell Viability Assay Cell line: M. pneumonia, M. fermentans, M. hominis and Ureaplasma spp. Concentration: Incubation time: 24 h for Ureaplasma spp., 48 h for M. hominis, 4 to 8 days for M. pneumonia Result: Showed inhibition with MIC90s of 0.031 μg/mL, ≤0.008 μg/mL, ≤0.008 μg/mL and 0.25 μg/mL against M. pneumonia, M. fermentans, M. hominis and Ureaplasma spp. strains, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS284756 | BMS 284756 | BMS-284756 | Garenoxacin. tradename Geninax

Quick Database Links

Gene Symbol

Antibacterial