Ganoderic acid C2

SKU: orb1297367

Description

Ganoderic acid C2 is a bioactive small molecule with demonstrated anti-inflammatory and anti-tumor-promoting properties in research settings. It functions by inhibiting histamine release, Epstein-Barr virus early antigen induction, and rat lens aldose reductase (IC50 = 3.8 µM). This compound is utilized in vitro for investigating metabolic and inflammatory pathways relevant to oncology and diabetic complications.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 103773-62-2
• MW: 518.68
• Purity: 98.00% (May vary between batches)
• Formula: C₃₀H₄₆O₇
• SMILES: [H][C@@]12C[C@H](O)C3=C(C(=O)C[C@]4(C)[C@H](C[C@H](O)[C@@]34C)[C@H](C)CC(=O)C[C@@H](C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
• Target: Reductase,Immunology/Inflammation related,Histamine Receptor
• Solubility: DMSO:50 mg/mL (96.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.93 mM)

Bioactivity

• Target IC50:
  Aldose reductase:3.8 µM(rat lens)
• In Vitro:
  The metabolites and pharmacokinetics of Ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aldose reductase, inhibit, Inhibitor, Inflammation related, Inflammationrelated, Immunology & Inflammation related, Immunology related, Immunology/Inflammation related, Immunologyrelated, Histamine Receptor, HistamineReceptor, Ganoderic acid C 2, Ganoderic acid C2, Ganoderic acid C-2

Compound Identifiers

PubChem CID

57396771