Ganfeborole HCl

SKU: orb1709527

Description

GSK656

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2131798-13-3
• MW: 293.94
• Purity: 99.88%
• Formula: C₁₀H₁₄BCl₂NO₄
• SMILES: Cl.NC[C@H]1OB(O)c2c1c(Cl)ccc2OCCO
• Target: Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (8.51 mM);DMSO:50 mg/mL (170.1 mM)

Bioactivity

• Target IC50:
  LeuRS (Mtb):0.2 μM
• In Vivo:
  GSK3036656 (0.4 mg/kg) demonstrated significant pharmacokinetic properties and efficacy against Mtb in a mouse TB infection model.
• In Vitro:
  GSK3036656 shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, GSK3036656 HCl, GSK-3036656, GSK3036656, GSK3036656, GSK 070, GSK 3036656, GSK 656, GSK070, GSK-070, GSK-656, GSK656 HCl, GSK656, Mtb LeuRS

Compound Identifiers

PubChem CID

134691736