Ganciclovir sodium

SKU: orb1305993

Description

Ganciclovir sodium is the sodium salt form of the antiviral drug Ganciclovir. It exhibits potent activity against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1), making it a key tool for in vitro and in vivo research in virology and antiviral drug development.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 107910-75-8
• MW: 278.22
• Purity: 99.47% (May vary between batches)
• Formula: C₉H₁₃N₅NaO₄
• SMILES: NC(NC1=C2N=CN1COC(CO)CO)=NC2=O.[Na]
• Target: Nucleoside Antimetabolite/Analog|||HSV|||Antifection
• Solubility: H2O:5 mg/mL (17.97 mM);PBS:5 mg/mL (17.97 mM);DMSO:3.06 mg/mL (11 mM)

Bioactivity

• Target IC50:
  FHV-1:5.2 μM
• In Vivo:
  In adult rats, the intracochlear diffusion of ganciclovir was shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion was observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir showed a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but became undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreased significantly in ganciclovir-treated newborn mice.
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• In Vitro:
  Ganciclovir showed activity against feline herpesvirus type-1 (FHV-1, IC50 = 5.2 microM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2'-Nor-2'-deoxyguanosine sodium, BW 759, BW 759 sodium, BW759, BW-759, Antibiotic, Analog, Cytovene IV sodium, Cytomegalovirus, DNA, CMV, CNS penetration, Feline herpesvirus type-1(FHV-1), group, HSV, HSV-1, Ganciclovir sodium, Ganciclovir, Inhibitor, Herpes simplex virus, herpes, inhibit, infection, Nucleoside Antimetabolite, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, RS-21592 sodium, replication, polymerase, serotype, orally active, viruse

Compound Identifiers

PubChem CID

135788865