Ganciclovir

SKU: orb1310384

Description

Ganciclovir, an acyclic analog of 2'-deoxyguanosine, is a potent antiviral agent effective against cytomegalovirus and other herpesviruses. It is widely used in research for in vitro antiviral assays and in vivo studies modeling CMV infections, particularly in immunocompromised settings.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 82410-32-0
• MW: 255.23
• Purity: 99.40% (May vary between batches)
• Formula: C₉H₁₃N₅O₄
• SMILES: C(OC(CO)CO)N1C2=C(N=C1)C(=O)N=C(N)N2
• Target: Antibiotic|||Nucleoside Antimetabolite/Analog|||Antifection|||HSV
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (9.8 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (195.9 mM)

Bioactivity

• Target IC50:
  FHV-1:5.2 μM
• In Vivo:
  In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cytomegalovirus, DNA, CNS penetration, CMV, 2'-Nor-2'-deoxyguanosine, Antibiotic, Analog, BW759, BW-759, BW 759, Herpes simplex virus, herpes, group, HSV, Ganciclovir, FHV-1, orally active, Nucleoside Antimetabolite/Analog, Nucleoside Antimetabolite, NucleosideAntimetabolite, inhibit, infection, Inhibitor, serotype, polymerase, replication, RS21592, RS-21592, RS 21592, viruse

Compound Identifiers

PubChem CID

135398740