Ganaplacide hydrochloride

SKU: orb1687366

Description

Ganaplacide hydrochloride (KAF156 HCl) is an oral imidazopyrimidine antimalarial that inhibits Plasmodium PI4K. It is active against P. falciparum, P. vivax, and artemisinin-resistant strains across blood and liver stages, making it a valuable tool for in vitro and in vivo studies of novel antimalarial mechanisms.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 2751586-94-2
• MW: 447.91
• Purity: 93.97% (May vary between batches)
• Formula: C₂₂H₂₄ClF₂N₅O
• SMILES: Cl.O=C(N1CCN2C(=NC(C3=CC=C(F)C=C3)=C2NC4=CC=C(F)C=C4)C1(C)C)CN
• Target: Antibiotic,PI4K,Parasite

Bioactivity

• In Vivo:
  Method: Ganaplacide hydrochloride (1-15 mg/kg) was administered orally for causal prophylaxis in rodent malaria model mice, and the prophylactic activity of KAF156 was monitored through blood smear analysis. Result: A single oral dose of 10 mg/kg Ganaplacide hydrochloride administered 2 hours before infection completely protected the mice.
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• In Vitro:
  Methods: The SYBR Green proliferation assay was employed to evaluate the inhibitory effect of Ganaplacide hydrochloride on laboratory-adapted Plasmodium falciparum strains and clinical dissociation strains. Results: The IC50 values of Ganaplacide hydrochloride against multiple drug-resistant strains ranged from 6 to 17.4 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antibiotic,PI4K,Parasite