Galanthaminone

SKU: orb1220497

Description

Galanthaminone is a cholinesterase (AChE) inhibitor is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Key Properties

• CAS Number: 510-77-0
• MW: 285.34
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₉NO₃
• SMILES: [H][C@]12CC(=O)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
• Target: AChR
• Solubility: In Vitro: DMSO : 10 mg/mL (35.05 mM)

Bioactivity

• In Vivo:
  Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
• In Vitro:
  Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Narwedine | Narwedin

Quick Database Links

Gene Symbol

AChR