Galanthamine hydrobromide

SKU: orb1310953

Description

Galanthamine hydrobromide

Research Area

Neuroscience

Key Properties

• CAS Number: 1953-04-4
• MW: 368.27
• Purity: 99.19%
• Formula: C₁₇H₂₁NO₃·HBr
• SMILES: Br.COc1ccc2CN(C)CCC34C=CC(O)CC3Oc1c24
• Target: Cholinesterase (ChE),AChR
• Solubility: DMSO:60 mg/mL (162.92 mM);H2O:7.4 mg/mL (20.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.72 mM)

Bioactivity

• Target IC50:
  AChE:410 nM
• In Vivo:
  Galantamine significantly increase the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity the nicotinic antagonist mecamylamine blocke the Protective effects of galantamine the neur Protective effects of galantamine are preserved even when first administered at 3 hours postischemia.
• In Vitro:
  Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex an the hippocampus region. Red-cell cholinesterase activity in blood Samples fro the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue Samples. Galanthamine (1 μM) activates Single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine 50 μM) activates Single-channel currents in outside-out patches excised from clonal PC12 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Cholinesterase (ChE), disease, disease (AD), Alzheimer's, acetylcholinesterase, AChE, neurodegenerative, Nicotinic acetylcholine receptors, nAChR, inhibit, Galantamine, Galantamine hydrobromide, Galantamine Hydrobromide, Galanthamine, Galanthamine HBr, Galanthamine hydrobromide, Galanthamine Hydrobromide, Inhibitor

Compound Identifiers

PubChem CID

21946319