Galanthamine HBr

SKU: orb1310953

Description

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50: 410 nM) and an allosteric potentiator of neuronal nicotinic receptors. It is widely used in neuroscience research for in vitro enzyme assays and in vivo studies related to cholinergic function, cognitive deficits, and neurodegenerative disease models.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 1953-04-4
• MW: 368.27
• Purity: >97%
• Formula: C₁₇H₂₁NO₃ · HBr
• SMILES: Br.COc1ccc2CN(C)CCC34C=CC(O)CC3Oc1c24
• Target: Acetylcholinesterase/Butyrylcholinesterase
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in Water (up to 12 mg/ml).

Bioactivity

• Target IC50:
  AChE:410 nM
• In Vivo:
  Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia.
• In Vitro:
  Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cholinesterase (ChE), disease, disease (AD), Alzheimer's, acetylcholinesterase, AChE, neurodegenerative, Nicotinic acetylcholine receptors, nAChR, inhibit, Galantamine, Galantamine hydrobromide, Galantamine Hydrobromide, Galanthamine, Galanthamine HBr, Galanthamine hydrobromide, Galanthamine Hydrobromide, Inhibitor

Compound Identifiers

PubChem CID

21946319