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GAD67 Antibody

GAD67 Antibody

Catalog Number: orb606596

DispatchUsually dispatched within 5-10 working days
$ 764.00
Catalog Numberorb606596
CategoryAntibodies
DescriptionThis mAb recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1). GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.
Species/HostMouse
ClonalityMonoclonal
Clone NumberGAD1/2391
Tested applicationsELISA, IHC-P, WB
ReactivityHuman
IsotypeMouse IgG1, kappa
ImmunogenA portion of amino acids 72-135 from the human protein were used as the immunogen for this GAD67 antibody.
Dilution rangeELISA (order BSA/sodium azide-free format for coating),Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Hazard InformationThis GAD67 antibody is available for research use only.
UniProt IDQ99259
StorageStore the GAD67 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the GAD67 antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
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