Fuzapladib

SKU: orb1741446

Description

Fuzapladib (IS-741) is a phospholipase A2 inhibitor that suppresses Mac-1 (integrin) expression, preventing inflammatory cell adhesion and tissue infiltration. It has been investigated in experimental models, including canine and rodent studies, for acute pancreatitis and associated systemic inflammation.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 141283-87-6
• MW: 379.4
• Purity: 99.87% (May vary between batches)
• Formula: C₁₅H₂₀F₃N₃O₃S
• SMILES: N(C(=O)C1CCCCC1)C2=C(NS(CC)(=O)=O)N=CC(C(F)(F)F)=C2
• Target: Integrin,Phospholipase
• Solubility: DMSO:3.8 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  Oral administration of Fuzapladib(IS-741) 50mg/kg significantly decreased the activity of myeloperoxidase (MPO) and the level of IL-8 in the ileum of rats for 7 consecutive days, and reduced the infiltration of inflammatory lesion multinucleate cells and Mac-1 positive cells, and effectively alleviated the ileitis induced by tritrobenzosulfonate (TNBS).
• In Vitro:
  Treatment with Fuzapladib(IS-741) 1μM for 3 h significantly inhibited the adhesion of HL-60 cells to HUVEC stimulated by lipopolysaccharide .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IS 741, IS741, IS-741, Fuzapladib, phospholipase A2

Compound Identifiers

PubChem CID

154529