FUREGRELATE

SKU: orb1309655

Description

FUREGRELATE is a selective thromboxane A2 synthase inhibitor used in research. It has been shown to attenuate the progression of pulmonary arterial hypertension in neonatal piglet models. This small molecule is a valuable tool for studying the role of TxA2 in cardiovascular and pulmonary diseases in both in vivo and in vitro experimental systems.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 85666-24-6
• MW: 253.25
• Purity: 99.71% (May vary between batches)
• Formula: C₁₅H₁₁NO₃
• SMILES: C(O)(=O)C1=CC=2C(O1)=CC=C(CC=3C=CC=NC3)C2
• Target: Prostaglandin Receptor,Others,PPAR
• Solubility: DMSO:50 mg/mL (197.43 mM)

Bioactivity

• In Vitro:
  A third group of piglets received FUREGRELATE (3 mg/kg, 2 or 3 times daily) at the induction of CH. In vivo hemodynamics confirmed a 2.55-fold increase of the pulmonary vascular resistance index (PVRI) in CH piglets (104±7 WU) compared to N piglets (40±2 WU). The CH piglets treated twice daily with FUREGRELATE failed to show improved PVRI, but FUREGRELATE three times daily lowered the elevated PVRI in CH piglets by 34% to 69±5 WU and ameliorated the development of right ventricular hypertrophy. Microfocal X-ray computed tomography (CT) scanning was used to estimate the diameter-independent distensibility term, α (% change in diameter per Torr). Pulmonary arterial distensibility in isolated lungs of CH piglets (α=1.0±0.1% per Torr) was lower than that of N piglets (α=1.5±0.1% per Torr) indicative of vascular remodeling. Arterial distensibility was partially restored in FUREGRELATE-treated CH piglets (α =1.2±0.1% per Torr) and microscopic evidence showing muscularization of small pulmonary arteries also was less prominent in these animals. Finally, isolated lungs of FUREGRELATE-treated piglets showed lower basal and vasodilator-induced transpulmonary pressures compared to CH animals.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FUREGRELATE, Furegrelate, TXA2R

Compound Identifiers

PubChem CID

3437