Furagin

SKU: orb1303000

Description

Furagin (Furazidine) is a nitrofuran antimicrobial agent primarily indicated for urinary tract infections. It is utilized in research to study its antibacterial mechanisms and efficacy in both in vitro assays and in vivo infection models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1672-88-4
• MW: 264.19
• Purity: 100.00%
• Formula: C₁₀H₈N₄O₅
• SMILES: [O-][N+](=O)c1ccc(\C=C\C=N\N2CC(=O)NC2=O)o1
• Target: Carbonic Anhydrase,Antibacterial,Antibiotic
• Solubility: DMSO:10 mg/mL (37.85 mM)

Bioactivity

• Target IC50:
  CA IX (human):260 nM (Ki)|CA XII (human):57 nM (Ki)
• In Vivo:
  A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment.
• In Vitro:
  The furagin concentrations in serum remain several hours above the MIC concentrations of many pathogenic bacteria. Despite the high concentrations in serum, the urine levels of furagin were generally lower than those of nitrofurantoin. The 24 hr recoveries in urine were 8--13% for furagin and about 36% for nitrofurantoin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

F 35, F35, F-35, Furazidin, Furazidine, Furagin, Inhibitor, NF416, NF-416, NF 416, inhibit, Akritoin, Antibacterial, Bacterial

Chemical structure of Furagin

Compound Identifiers

PubChem CID

6870646