FT827

SKU: orb1707291

Description

FT827 is a covalent, selective USP7 inhibitor (Ki=4.2 µM, Kd=7.8 µM) that targets the catalytic site of its autoinhibited conformation. This compound is a valuable research tool for investigating USP7's role in oncology, supporting both in vitro biochemical assays and cellular mechanism-of-action studies.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1959537-86-0
• MW: 548.61
• Purity: 98.63% (May vary between batches)
• Formula: C₂₇H₂₈N₆O₅S
• SMILES: Cn1ncc2c1ncn(CC1(O)CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1NS(=O)(=O)C=C)c2=O
• Target: DUB
• Solubility: DMSO:80 mg/mL (145.82 mM)

Bioactivity

• Target IC50:
  USP7:（kd）7.8 μM|USP7:（ki）4.2 μM
• In Vitro:
  After incubating MCF7 cell extracts with DMSO, 1 µM or 10 µM of FT671, FT827, or 50 µM of P22077 for 60 minutes, the results demonstrated the target-specific engagement of USP7 in MCF7 cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FT 827, FT827, FT-827, USP7

Compound Identifiers

PubChem CID

121435663