FT709

SKU: orb1686668

Description

FT709 is a potent and selective inhibitor of the deubiquitinating enzyme USP9X (IC50=82 nM). By inhibiting USP9X, it reduces cellular levels of Makorin and ZNF598, thereby disrupting ribosomal quality control mechanisms. This tool compound is useful for studying protein homeostasis and ribosome-associated degradation pathways in cellular models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2413991-74-7
• MW: 498.51
• Purity: 98.13% (May vary between batches)
• Formula: C₂₃H₂₂N₄O₇S
• SMILES: S(=O)(=O)(N1CC2=C(C1)CN(C([C@@H](O)C3=C4C(OC(C)=N4)=CC=C3)=O)C2)C=5C=C6C(=NC5)OCCO6
• Target: DUB
• Solubility: DMSO:80 mg/mL (160.48 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.62 mM)

Bioactivity

• Target IC50:
  USP9X:82 nM
• In Vitro:
  In HCT116 cells, treatment with 10 µM FT709 for 24 hours downregulated the expression levels of ZNF598 (a ubiquitin E3 ligase) and centrosomal protein CEP55 .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FT 709

Compound Identifiers

PubChem CID

146448154