FT671

SKU: orb1708753

Description

FT671

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1959551-26-8
• MW: 533.48
• Formula: C₂₄H₂₃F₄N₇O₃
• SMILES: OC1(Cn2cnc3n(ncc3c2=O)-c2ccc(F)cc2)CCN(CC1)C(=O)C[C@@H](C(F)F)n1ccc(F)n1
• Target: DUB
• Solubility: DMSO:50 mg/mL (93.72 mM)

Bioactivity

• Target IC50:
  USP7:52 nM
• In Vivo:
  FT671 is well-to related even at high doses. FT671 (100 mg/kg and 200 mg/kg, oral gavage, daily) treatment in mice causes an obviously dose-dependent inhibition of tumor growth.
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• In Vitro:
  FT671 promotes the degradation of N-Myc and enhances p53 levels in the neuroblastoma cell line IMR-32, as well as in HCT116 and bone osteosarcoma (U2OS) cell lines. This results in the activation of p53 target genes, including BBC3 (which encodes PUMA), CDKN1A (p21), RPS27L (S27L), and MDM2. Additionally, in the MM.1S multiple myeloma cell line, FT671 stabilizes p53, associated with an upsurge in MDM2 ubiquitination. This stabilization of p53 triggers the expression of its target genes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP7, FT671, FT-671, FT 671

Compound Identifiers

PubChem CID

121457027