FRAX486 HCL(1232030-35-1 free base)

SKU: orb1300417

Description

FRAX486 hydrochloride is a potent and selective p21-activated kinase (PAK) inhibitor, demonstrating IC50 values of 14 nM for PAK1, 33 nM for PAK2, 39 nM for PAK3, and 575 nM for PAK4. This small molecule is a valuable research tool for studying PAK signaling in cancer cell proliferation, neuronal morphology, and other cellular processes in both in vitro and in vivo models.

Research Area

Signal Transduction

Key Properties

• Target: PAK
• Molecular Weight: 549.86
• Purity: 99.17%
• Formula: C₂₅H₂₄Cl₃FN₆O
• SMILES: FC1=CC(NC2=NC=C3C(N(C(C(C4=CC=C(C=C4Cl)Cl)=C3)=O)CC)=N2)=CC=C1N5CCNCC5.[H]Cl

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PAK4, PAK3, PAK2, PAK1, FRAX486 HCL(1232030 35 1 free base), FRAX486 HCL(1232030351 free base), FRAX-486 HCL(1232030-35-1 free base), FRAX486 HCL(1232030-35-1 free base)

Compound Identifiers

PubChem CID

156598960