Fostemsavir

SKU: orb1221717

Description

Fostemsavir, also known as BMS-663068, is a oral, safe and effective HIV-1 attachment inhibitor. BMS-663068 is a prodrug of the small-molecule inhibitor BMS-626529, which inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells.(In Vivo):Fostemsavir (BMS-663068) has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 864953-29-7
• MW: 583.5
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₆N₇O₈P
• SMILES: COc1cnc(-n2cnc(C)n2)c2n(COP(O)(O)=O)cc(C(=O)C(=O)N3CCN(CC3)C(=O)c3ccccc3)c12
• Target: Adrenergic Receptor
• Solubility: DMSO : ≥ 100 mg/mL 171.38 mM H2O : 20 mg/mL 34.28 mM

Bioactivity

• In Vivo:
  Fostemsavir (BMS-663068) has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS-663068 | BMS 663068 | Fostemsavir

Quick Database Links

Gene Symbol

Adrenergic Receptor