Fosamprenavir Calcium Salt

SKU: orb1685412

Description

Fosamprenavir Calcium Salt

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 226700-81-8
• MW: 623.67
• Purity: 99.24%
• Formula: C₂₅H₃₄CaN₃O₉PS
• SMILES: [Ca++].CC(C)CN(C[C@@H](OP([O-])([O-])=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
• Target: Endogenous Metabolite,HIV Protease
• Solubility: DMSO:1.8 mg/mL (2.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.6 mM);H2O:0.25 mg/mL (0.4 mM)

Bioactivity

• In Vivo:
  Oral gavage of DATS significantly retarded growth of PC-3 xenografts in athymic mice without causing weight loss. For instance, 20 days after starting therapy, the average tumor volume in control mice was approximately 3-fold higher compared with DATS-treated mice. Tumors from DATS-treated mice exhibited a markedly higher count of apoptotic bodies compared with control tumors. Consistent with the results in cultured PC-3 cells, the DATS-mediated suppression of PC-3 xenograft growth correlated with induction of proapoptotic proteins Bax and Bak. Although DATS treatment inhibited migration of cultured PC-3 cells in association with down-regulation of vascular endothelial growth factor receptor-2 protein, formation of new blood vessels was comparable in tumors of control and DATS-treated mice as judged by CD31 immunostaining.
• Animal Research:
  DATS was given orally (6 micromoL, thrice weekly) to male athymic mice s.c. implanted with PC-3 cells. Tumor sections from control and DATS-treated mice were examined for apoptotic bodies by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. Protein levels of apoptosis and cell cycle regulating proteins in tumor tissues of control and DATS-treated mice were determined by immunoblotting. The effect of DATS treatment on in vivo angiogenesis was determined by immunohistochemical analysis of CD31 in tumors.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diallyl, Diallyl Trisulfide, Diallyl Trisulfide, Fosamprenavir Calcium Salt, Human immunodeficiency virus, GW433908G, HIV, HIV Protease, HIVProtease, Inhibitor, inhibit

Compound Identifiers

PubChem CID

131535