Folitixorin

SKU: orb1705138

Description

Folitixorin (ANX-510) is an active folate cofactor essential for thymidylate synthesis, exhibiting potential antitumor properties. It is utilized in oncology research, particularly in studies investigating chemotherapeutic modulation and rescue strategies in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 3432-99-3
• MW: 457.44
• Formula: C₂₀H₂₃N₇O₆
• SMILES: [H][C@@](CCC(O)=O)(NC(=O)c1ccc(cc1)N1CC2CNc3[nH]c(N)nc(=O)c3N2C1)C(O)=O
• Target: Others
• Solubility: H2O:4 mg/mL (8.74 mM);DMSO:1 mg/mL (2.19 mM)

Bioactivity

• In Vivo:
  5-FU (30 mg/kg, intravenous injection) and Folitixorin (15 mg/kg or 30 mg/kg, intravenous injection) were administered intrahepatically to rodents with colon adenocarcinoma cell suspensions. The combination of these two drugs abolished tumor uptake, regardless of folic acid dose.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5,10-Methylenetetrafolate, ANX 510, ANX-510, ANX510, ANX510 free acid, ANX-510 free acid, Folitixorin

Compound Identifiers

PubChem CID

135400185