Fmoc-PEG12-NHS ester

SKU: orb1307420

Description

Fmoc-PEG12-NHS ester is a heterobifunctional linker used to construct PROTAC molecules for targeted protein degradation research. Its hydrophilic PEG spacer enhances solubility and pharmacokinetics, facilitating both in vitro cellular studies and in vivo preclinical investigations of proteolysis-targeting chimeras.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2227246-92-4
• MW: 937.03
• Purity: ≥98% (May vary between batches)
• Formula: C₄₆H₆₈N₂O₁₈
• SMILES: C(OC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alkyl/ether, Inhibitor, inhibit, Fmoc PEG12 NHS ester, FmocPEG12NHS ester, Fmoc-PEG-12-NHS ester, Fmoc-PEG12-NHS ester, PEGs, PROTAC Linker, PROTACLinker, PROTAC Linkers

Compound Identifiers

PubChem CID

11535302