Fluvastatin

SKU: orb1705076

Description

Fluvastatin is a potent, competitive HMG-CoA reductase inhibitor (IC50: 8 nM) used to lower plasma cholesterol. It also reduces oxidative stress in vascular smooth muscle cells via an Nrf2 pathway, making it a research tool for studying atherosclerosis and cardiovascular disease in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 93957-54-1
• MW: 411.47
• Purity: 98.94% (May vary between batches)
• Formula: C₂₄H₂₆FNO₄
• SMILES: C(=C/[C@@H](C[C@@H](CC(O)=O)O)O)\C1=C(C=2C(N1C(C)C)=CC=CC2)C3=CC=C(F)C=C3
• Target: Autophagy,HMG-CoA Reductase
• Solubility: H2O:Insoluble;DMSO:252.5 mg/mL (613.65 mM)

Bioactivity

• Target IC50:
  HMG-CoA reductase:8 nM

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cranoc, Canef, HMGCoAReductase, HMGCoA Reductase, HMG-CoA Reductase (HMGCR), Lescol, Fluvastatin, Vastin, XU-62320, XU62320, XU 62320

Compound Identifiers

PubChem CID

1548972