Fluspirilene

SKU: orb1707307

Description

Fluspirilene is a potent, non-competitive antagonist of L-type calcium channels (IC50: 0.03 µM). This long-acting antipsychotic is used in schizophrenia research and serves as a pharmacological tool for studying calcium signaling in both cellular and animal models of neuropsychiatric disorders.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1841-19-6
• MW: 475.57
• Purity: 97.94% (May vary between batches)
• Formula: C₂₉H₃₁F₂N₃O
• SMILES: Fc1ccc(cc1)C(CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1
• Target: Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.21 mM);DMSO:20.71 mg/mL (43.55 mM)

Bioactivity

• Target IC50:
  Ca2+ channel, L-type:0.03 μM
• In Vivo:
  Fluspirilene obviously prolongs the survival of the TGS04 mouse model. Mice treated with fluspirilene display a remarkable reduction in tumor size.
• In Vitro:
  Fluspirilene (1.25, 2.5, and 5 μM) demonstrates the inhibition of proliferation of T98, U87, and all GSC lines, while Fluspirilene (2.5 and 5 μM) inhibits the proliferation of U251 and SNB19. Fluspirilene decreases the viability and suppresses the sphere-forming of glioma stem cell lines in a dose-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Redeptin, R6218, R-6218, R 6218, Fluspirilene, L-type calcium channel, CalciumChannel, Calcium Channel

Compound Identifiers

PubChem CID

3396