Flunarizine dihydrochloride

SKU: orb1310274

Description

Flunarizine dihydrochloride is a selective calcium channel blocker with calmodulin antagonistic and H1 antihistamine properties. It is utilized in research for migraine and epilepsy prophylaxis, as well as in studies on peripheral vascular disease and vertigo, supported by both in vitro binding assays and in vivo pharmacological models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 30484-77-6
• MW: 477.42
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₂₈Cl₂F₂N₂
• SMILES: Cl.Fc1ccc(cc1)C(N1CCN(C/C=C/c2ccccc2)CC1)c1ccc(F)cc1.Cl
• Target: Dopamine Receptor,Sodium Channel,Calcium Channel
• Solubility: DMSO:50 mg/mL (104.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.19 mM);Ethanol:2.4 mg/mL (5.03 mM)

Bioactivity

• Target IC50:
  Ca2+ channel:68 nM(Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopamine, DopamineReceptor, Dopamine Receptor, Ca channels, CalciumChannel, Calcium Channel, Ca2+ channels, Flunarizine, Flunarizine 2HCl, Flunarizine dihydrochloride, Flunarizine Dihydrochloride, Inhibitor, Na channels, Na+ channels, inhibit, KW3149, KW-3149, KW 3149, SodiumChannel, Sodium Channel, R 14950, R14950, R-14950

Compound Identifiers

PubChem CID

5282407