Flecainide acetate

SKU: orb1299967

Description

Flecainide acetate

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54143-56-5
• MW: 474.39
• Purity: >98%
• Formula: C₁₇H₂₀F₆N₃O₃  C₂H₄O₂
• SMILES: CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 45 mg/ml) or in Water (up to 10 mg/ml)

Bioactivity

• In Vivo:
  Flecainide (acetate) is an effective antiarrhythmic agent, free of side effects and when used orally is capable of terminating and controlling relatively resistant supraventricular tachycardia in children.
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• Animal Research:
  A total of 8 infants were treated with flecainide for refractory tachyarrhythmia's. Diagnosis on electrocardiogram (ECG) was atrioventricular reentry tachycardia (AVRT) in 5, atrial ectopic tachycardia (AET) in 2, a combination of AVRT and atrioventricular nodal reentry tachycardia (AVNRT) in 1. All patients had failed trial of antiarrhythmic drugs prior to presentation: digoxin and propranolol in 7, amiodarone in 3, cardioversion in 1. Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2. There were no side effects noted. Four episodes of recurrence were noted in 3 patients over 2 years, all of which responded to dose increase. Mean follow up time is 24.75 months.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Na channels, Na+ channels, Nav1.5 channel, inhibit, Flecainide, Flecainide (acetate), Flecainide acetate, Flecainide Acetate, Inhibitor, R 818, R818, R-818, SodiumChannel, Sodium Channel

Compound Identifiers

PubChem CID

41022