FK962

SKU: orb1299468

Description

FK962 is a small molecule that enhances somatostatin release and demonstrates cognitive-enhancing properties. It is utilized in neuroscience research to study cognitive function and neuropeptide regulation in both in vitro assays and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 283167-06-6
• MW: 264.3
• Purity: 99.78% (May vary between batches)
• Formula: C₁₄H₁₇FN₂O₂
• SMILES: CC(=O)N1CCC(CC1)NC(=O)c1ccc(F)cc1
• Target: Others,Somatostatin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.78 mM);DMSO:9 mg/mL (34.05 mM)

Bioactivity

• In Vitro:
  FK962 or GDNF were found to significantly induce neurite elongation. The GDNF antibody significantly inhibited elongation induced by FK962.
• Cell Research:
  Dissociated, cultured trigeminal ganglion cells, containing neuronal and Schwann cells were cultured for 48 h with or without FK962. Neuronal elongation was evaluated by immunostaining with a neurofilament-specific antibody. Culture with or without GDNF, or with antibody against GDNF, was used to determine the role of GDNF in FK962-induced neurite elongation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cognitive, Alzheimer, FK 962, FK962, FK-962, Inhibitor, inhibit, Somatostatin release, somatostatin

Compound Identifiers

PubChem CID

9816738