FITM

SKU: orb1299949

Description

FITM is a highly potent and selective negative allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1), exhibiting a Ki of 2.5 nM. This small molecule is a valuable research tool for investigating mGlu1 function in neurological disorders, with applications in both in vitro binding assays and in vivo pharmacological studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 932737-65-0
• MW: 371.43
• Purity: 99.23% (May vary between batches)
• Formula: C₁₈H₁₈FN₅OS
• SMILES: CC(C)Nc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1
• Target: GluR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.77 mM);DMSO:150 mg/mL (403.84 mM)

Bioactivity

• Target IC50:
  mGlu1:2.5 nM(KI)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FITM, Inhibitor, Metabotropic glutamate receptors, mGluR, mGluR1, inhibit

Compound Identifiers

PubChem CID

16660135