FH1

SKU: orb1306477

Description

FH1 (NSC-12407, BRD-K4477) is a small molecule compound that augments hepatocyte functionality and drives the differentiation of induced pluripotent stem cell (iPSC)-derived hepatocytes. It is utilized in liver disease modeling, drug metabolism studies, and regenerative medicine research, primarily in vitro.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2719-05-3
• MW: 282.34
• Purity: 99.95% (May vary between batches)
• Formula: C₁₇H₁₈N₂O₂
• SMILES: CC(=O)Nc1ccc(Cc2ccc(NC(C)=O)cc2)cc1
• Target: Others,Reductase
• Solubility: DMSO:4.62 mg/mL (16.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.54 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Within hepatocytes, FH1(BRD-K4477) facilitates the differentiation of fully-integrated iHeps into a mature state, enhancing cellular functionality.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD-K 4477, BRD-K4477, BRD-K-4477, NSC12407, NSC-12407, iPSC, iPS-derived hepatocytes, IPS, NSC 12407, inhibit, hALB, FH1, FH-1, FH 1, Inhibitor, hRXR, hNTCP, hHNF4α

Compound Identifiers

PubChem CID

94990