Fexinidazole

SKU: orb1224531

Description

Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.(In Vitro):Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.(In Vivo):Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities.

Key Properties

• CAS Number: 59729-37-2
• MW: 279.31
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₃N₃O₃S
• SMILES: O=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-]
• Target: antiparasitic
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities. Animal model: Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesiense. Dosage: 20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO). Administration: IP or PO; daily; four consecutive days. Result: Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.
• In Vitro:
  Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fexinidazole | Hoe-239 | Hoe 239 | Hoe239

Quick Database Links

Gene Symbol

antiparasitic