Fesoterodine fumarate

SKU: orb1308533

Description

Fesoterodine fumarate

Research Area

Neuroscience

Key Properties

• CAS Number: 286930-03-8
• MW: 527.65
• Purity: 98.00%
• Formula: C₂₆H₃₇NO₃·C₄H₄O₄
• SMILES: OC(=O)C=CC(O)=O.CC(C)N(CCC(C1=CC=CC=C1)C1=C(OC(=O)C(C)C)C=CC(CO)=C1)C(C)C
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.25 mM);H2O:92 mg/mL (174.36 mM);DMSO:93 mg/mL (176.25 mM);Ethanol:93 mg/mL (176.25 mM)

Bioactivity

• In Vitro:
  Fesoterodine is rapidly and extensively converted to 5 hMT, such tha the pharmacologic activity appears to be primarily attributable to 5 hMT. Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioli and-binding studies. Fesoterodine causes a rightward shift o the concentration response curve for carbachol with no depression o the maximum in rat bladder strips, and concentration dependently reduces contractions induced by electrical ffield stimulation (EFS). Fesoterodine is hydrolyzed by nonspecific esterases to 5 hydroxmethyl tolterodine (5 hMT), which in the active metabolite and is responsible for All its antimuscarinic activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Toviaz, SPM 907, SPM7605, SPM907, SPM-907, receptor, Fesoterodine, Fesoterodine Fumarate, Fesoterodine fumarate, Inhibitor, inhibit, Muscarinic acetylcholine receptor, muscarinic, mAChR, OAB, orally, overactive, 5-HMT, bladder, antimuscarinic, Desfesoterodine

Compound Identifiers

PubChem CID

74344602