Ferrous Bisglycinate

SKU: orb1222541

Description

Ferrous Bisglycinate is used in the fortification of infant formulations and foods.(In Vitro):Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability.Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells.(In Vivo):Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice.

Key Properties

• CAS Number: 20150-34-9
• MW: 203.96
• Purity: >98% (HPLC)
• Formula: C₄H₈FeN₂O₄
• SMILES: [Fe++].NCC([O-])=O.NCC([O-])=O
• Target: IDO
• Solubility: In Vitro: 0.1 M HCL : 2 mg/mL (9.90 mM)

Bioactivity

• In Vivo:
  Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice. Animal model: Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS). Dosage: 500 mg/kg iron. Administration: p.o. (add to the diet) for 10 days. Result: Had the best survival rates (100%).
• In Vitro:
  Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability. Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells. Cell Viability Assay Cell line: Caco-2 cells. Concentration: 0, 25, 50, 100, 200 μM. Incubation time: 2 hours. Result: Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells. Western blot analysis. Cell line: Caco-2 cells. Concentration: 25 μM. Incubation time: 2 hours. Result: Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IDO