FDI-6

SKU: orb1303315

Description

FDI-6 is a potent and selective small molecule inhibitor of the FOXM1 transcription factor, disrupting its DNA-binding activity and suppressing downstream target gene expression. Its application in both in vitro and in vivo research models facilitates the study of FOXM1's role in processes such as cell cycle progression and oncogenesis.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 313380-27-7
• MW: 437.43
• Purity: 99.94% (May vary between batches)
• Formula: C₁₉H₁₁F₄N₃OS₂
• SMILES: Nc1c(sc2nc(cc(c12)C(F)(F)F)-c1cccs1)C(=O)Nc1ccc(F)cc1
• Target: Others
• Solubility: DMSO:50 mg/mL (114.3 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.72 mM)

Bioactivity

• In Vitro:
  FDI-6 specifically downregulates FOXM1-activated genes with FOXM1 occupancy confirmed by ChIP-PCR. This small molecule-mediated effect is selective for FOXM1-controlled genes with no effect on genes regulated by homologous forkhead family factors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, FDI 6, FDI6, FDI-6, FOXM1, Inhibitor

Compound Identifiers

PubChem CID

5175738