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FC-14367

SKU: orb3135082

Description

FC-14367 is a PROTAC degrader targeting the HIV-1Nef protein. It forms a ternary complex by binding Nef with CereblonE3 ubiquitin ligase, inducing ubiquitination of Nef and its subsequent proteasomal degradation. This restores cell surface CD4 and MHC-I expression, inhibiting HIV-1 replication. FC-14367 is useful for research on HIV infection and AIDS.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number3066893-65-7
MW740.18
FormulaC38H35ClFN7O6
SMILESO=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCC(=O)N4CCC(C5=NN(C(O)=C5CCC6=CC=C(F)C=C6)C7=NC=8C=C(Cl)C=CC8N7)CC4)C3C2)CC1
TargetHIV Protease,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

FC-14367 (orb3135082)

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