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FAPy-adenine

SKU: orb1706192

Description

FAPy-adenine

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number5122-36-1
MW153.14
FormulaC5H7N5O
SMILESNc1ncnc(N)c1NC=O
TargetOthers
SolubilityDMSO:15 mg/mL (97.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.53 mM)

Bioactivity

In Vivo
There is an increased trend in the levels of FAPy-adenine in the AD brain. The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.
In Vitro
In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

4,6-diamino-5-n-formamidopyrimidine, Human Endogenous Metabolite, FAPy adenine, FAPyadenine, FAPy-adenine

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Key Properties

No computed properties available.

Protocol Information