EZH2-IN-7

SKU: orb1744328

Description

EZH2-IN-7 is a potent and selective EZH2 inhibitor targeting oncogenic SET domain mutations (e.g., Y641, A677G) that drive H3K27me3-dependent tumor growth. It is a valuable chemical probe for studying epigenetics in cancers like lymphoma and prostate cancer, with utility in both in vitro cellular assays and in vivo xenograft models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2659225-28-0
• MW: 563.75
• Formula: C₃₁H₃₇D₂N₅O₃S
• SMILES: C(NC(C1=C(SC)C=C(C)NC1=O)([2H])[2H])(=O)C=2C=3C(N([C@H](C)C4(CCC(OC)CC4)[H])C2C)=CC=C(C3)C=5C=NN(C)C5
• Target: Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156799541