EZH2-IN-15

SKU: orb1741376

Description

SHR2554 (EZH2-IN-15) is a selective EZH2 inhibitor. This compound is a valuable research tool for investigating the role of EZH2 in oncology and immunology, including its regulation of Treg function and innate immunity in tumor models, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2098545-98-1
• MW: 548.72
• Purity: 99.88%
• Formula: C₃₂H₄₄N₄O₄
• SMILES: CCN(C1CCOCC1)c1cc2oc(CN3CCCCC3)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC
• Target: Histone Methyltransferase
• Solubility: DMSO:50 mg/mL (91.12 mM)

Bioactivity

• In Vitro:
  As measured by CellTiter-Glo Luminescent Cell Viability Assay Method, EZH2-IN-15 IC50 = 0.87 nM for EZH2 wild type and IC50 = 1.63 nM for H3K27me3 in Pfeiffer cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone Methyltransferase, HistoneMethyltransferase, EZH2, SHR2554

Compound Identifiers

PubChem CID

135332280