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EZH2 Antibody for Epigenetics, PRC2 and Cancer Research
High-quality EZH2 antibodies for WB, IHC, IF, FC and chromatin studies.
EZH2 antibodies are essential tools for studying Enhancer of Zeste Homolog 2 (EZH2), a key histone methyltransferase and catalytic subunit of the Polycomb Repressive Complex 2 (PRC2). As a major regulator of H3K27 trimethylation (H3K27me3), EZH2 plays a critical role in gene silencing, chromatin regulation, and cancer progression.
At Biorbyt, we provide a comprehensive portfolio of EZH2 antibodies including polyclonal, monoclonal, recombinant, and phospho-specific antibodies. These are validated across WB, IHC, IF, FC and IP, with strong performance in human and mouse samples, while also supporting extended model systems.
What is EZH2 and its role in PRC2 and cancer
EZH2 (KMT6A) is a histone methyltransferase and the catalytic core of the Polycomb Repressive Complex 2 (PRC2), responsible for catalysing H3K27 trimethylation (H3K27me3), a key epigenetic mark associated with transcriptional repression.
As part of PRC2, EZH2 regulates:
- Epigenetic gene silencing
- Chromatin compaction and transcriptional repression
- Stem cell maintenance and differentiation
- X-chromosome inactivation
Beyond its canonical role in chromatin regulation, EZH2 is also a critical driver of cancer progression.
EZH2 in cancer and epigenetics
- EZH2 overexpression promotes tumour growth and metastasis
- Drives silencing of tumour suppressor genes
- Associated with poor prognosis in multiple cancers
- Key target for epigenetic inhibitors
Due to its central role in both chromatin regulation and cancer biology, EZH2 is one of the most widely studied epigenetic targets.
What are EZH2 antibodies used for?
Key research applications include:
- PRC2 complex and chromatin regulation
- Cancer biology and tumour progression
- Epigenetic silencing and H3K27me3 studies
- Stem cell and developmental biology
- Drug response and inhibitor validation
Common laboratory techniques:
- Immunohistochemistry (IHC-P, IHC-Fr)
- Immunofluorescence (IF)
- Flow cytometry (FC)
- Western blot (WB)
- Immunoprecipitation (IP)
- ELISA
Recommended EZH2 antibodies by application
Below is a selection of EZH2 antibodies optimised for different applications in human and mouse research.
SKU | Product Name | Applications | Size | Price |
|---|---|---|---|---|
orb5975 | Most popular EZH2 Rabbit polyclonal antibody (IHC / IF recommended) | FC, IF, IHC-Fr, IHC-P | 50 μl | $250 |
orb1151968 | Recombinant EZH2 Rabbit monoclonal antibody (WB / reproducibility) | IF, IHC, WB | 25 μl | $180 |
orb626869 | ELISA, IF, IP, WB | 50 μg | $220 | |
orb546272 | ELISA, FC, IP, WB | 100 μg | $450 | |
orb229775 | FC, IHC | 100 μl | $350 |
EZH2 inhibitor and antibody combination strategies
EZH2 is a major target in epigenetic drug development, particularly in cancer therapeutics. Combining EZH2 inhibitors with antibody-based detection is a widely used strategy.
- Monitor EZH2 protein expression changes
- Assess reduction of H3K27me3 after inhibition
- Validate drug efficacy in cellular and tissue models
- Study resistance mechanisms
Typical workflow:
- Treat cells with EZH2 inhibitors
- Detect EZH2 expression (WB / IF / IHC)
- Measure downstream effects (e.g. H3K27me3 levels)
Recommended antibodies:
- orb1151968 – recombinant, high reproducibility
- orb5975 – strong IF/IHC signal
- orb626869 – suitable for IP studies
EZH2 antibodies for non-mammalian models
In addition to standard human and mouse systems, EZH2 is increasingly studied in non-mammalian models, particularly in developmental biology and comparative epigenetics.
Zebrafish (Danio rerio)
- ezh2 Antibody [orb859615]
- Suitable for ELISA and WB
Xenopus models
- EZH2 Antibody [orb734197]
- Reactivity confirmed in Xenopus
These options complement core human and mouse EZH2 research workflows.
Why choose Biorbyt EZH2 antibodies?
- Validated for IHC, IF, FC, WB and IP
- Coverage of total and modified EZH2 targets
- Available in polyclonal, monoclonal and recombinant formats
- Strong performance in human and mouse samples
- Extended support for specialised model organisms
Conclusion
Biorbyt provides a comprehensive portfolio of EZH2 antibodies designed for epigenetics, PRC2 research, and cancer biology.
By combining antibody-based detection with inhibitor-based studies, researchers can gain deeper insights into chromatin regulation and therapeutic targeting of EZH2.