Exatecan-amide-cyclopropanol

SKU: orb1686416

Description

Exatecan-amide-cyclopropanol is a potent DNA topoisomerase I inhibitor with sub-nanomolar IC50 values against SK-BR-3 (0.12 nM) and U87 (0.23 nM) cell lines. It is a key research tool for investigating topoisomerase-mediated cytotoxicity in both in vitro and in vivo oncology studies.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2414254-34-3
• MW: 519.52
• Purity: 98.30% (May vary between batches)
• Formula: C₂₈H₂₆FN₃O₆
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](NC(=O)C6(O)CC6)c(c3Cn1c2=O)c45
• Target: Topoisomerase,Others
• Solubility: DMSO:2 mg/mL (3.85 mM)

Bioactivity

• Target IC50:
  U87 cells:0.23|SKBR3 cells:0.12 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Cytotoxin, ADCCytotoxin

Compound Identifiers

PubChem CID

146505730