Euscaphic acid

SKU: orb1297535

Description

Euscaphic acid is a bioactive small molecule with demonstrated anti-diabetic and anti-inflammatory properties. Its mechanism involves disrupting the TRAF6/IRAK1/TAK1 complex formation, thereby inhibiting downstream IKK and MAPK signaling to suppress NF-κB activation. This compound is a valuable research tool for studying inflammatory pathways in both cellular and animal models of metabolic and inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 53155-25-2
• MW: 488.7
• Purity: 98.93% (May vary between batches)
• Formula: C₃₀H₄₈O₅
• SMILES: [H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@@H](O)C2(C)C
• Target: Prostaglandin Receptor,PI3K,NO Synthase,Apoptosis,LDL,DNA/RNA Synthesis
• Solubility: DMSO:50 mg/mL (102.31 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.12 mM)

Bioactivity

• Target IC50:
  DNA polymerase α (calf):61 μM (IC50)|DNA polymerase β (rat):108 μM (IC50)
• In Vitro:
  Isolated aorta was used to test the anti-contraction effects and the possible mode of action(s) of the EA (1*10 -7 M) and (3*10 -7 M) isolated from Crataegus azarolus var. aronia L. Euscaphic acid showed high anti-contraction effects on norepinephrin (NE), (1*10 -9 -10 -4 M) induced contraction in aortic smooth muscle cells in endothelium-intact, endothelium-denuded, and aortic rings pre-incubated with potassium (K + )-channels blocker (tetraethylammonium, TEA), prostaglandin I 2 (PGI ) inhibitor (indomethacin) and cyclic guanosine monophosphate (cGMP) inhibitor ( methylene blue). On the other hand, other K 2 channels subtype blockers glibenclamide (GLIB); barium chloride (BaCl ) and 4-aminopyridine (4-AP) demonstrated that adenosine triphosphate sensitive K + (K ATP ), inwardly rectifying K 2 + (K ir ) and voltage-dependent K ) channels played no role in anti-contraction induced by EA. Furthermore, the role of L-types calcium (Ca ) channels in EA anti-contractile effects on aortic smooth muscle cells was proved, by using the Ca -channel blocker verapamil, as indicated by the production of a potent anti-contraction effect . The results of the current study indicate that the anti-contraction effects of EA may be due to the activation of calcium dependent, K ) channels and blocking of L-type Ca ++ channels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, Apoptosis, NO Synthase, inhibit, Inhibitor, NOSynthase, LDL, Euscaphic acid, PGE, Phosphoinositide 3-kinase, PI3K, ProstaglandinReceptor, Prostaglandin Receptor, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

471426