Etiprednol dicloacetate

SKU: orb1697262

Description

Etiprednol dicloacetate (BNP-166) is a synthetic corticosteroid with anti-inflammatory properties, notably inhibiting eosinophil accumulation. It serves as a research tool for studying inflammatory airway diseases like asthma and has been investigated in models of Crohn's disease.

Research Area

Cell Biology

Key Properties

• CAS Number: 199331-40-3
• MW: 485.4
• Purity: 99.74%
• Formula: C₂₄H₃₀Cl₂O₆
• SMILES: O(C(C(Cl)Cl)=O)[C@@]1(C(OCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
• Target: TNF,Others
• Solubility: DMSO:55 mg/mL (113.31 mM)

Bioactivity

• In Vivo:
  Etiprednol dicloacetate (0-100 μg/kg; intranasal inhalation) reduces peribronchial eosinophilia in the lungs of allergen-sensitized and challenged rats. It is well-tolerated in rats and dogs at doses of up to 20 mg/kg administered orally over 28 days. Etiprednol dicloacetate (0.1 μg/kg; intranasal inhalation) inhibits eosinophil accumulation in rats induced by antigen exposure.
• In Vitro:
  Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production in human blood.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BNP166, BNP-166, BNP 166, Etiprednol dicloacetate

Compound Identifiers

PubChem CID

9935073