Escitalopram Oxalate

SKU: orb1300720

Description

Escitalopram Oxalate is the active S-enantiomer of citalopram and a potent selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. It is widely used in neuroscience research to study depression, anxiety, and serotonin transporter (SERT) function in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 219861-08-2
• MW: 414.43
• Purity: 99.90% (May vary between batches)
• Formula: C₂₂H₂₃FN₂O₅
• SMILES: OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
• Target: 5-HT Receptor,Serotonin Transporter
• Solubility: H2O:20.7 mg/mL (49.95 mM);DMSO:50 mg/mL (120.65 mM)

Bioactivity

• Target IC50:
  5-HT:0.89 nM(Ki)
• In Vitro:
  Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-Citalopram, (S)-(+)Citalopram oxalate, 5-HT, 5HT Receptor, 5HTReceptor, 5-HTT, antidepressant, depression, cognitive, Citalopram Oxalate, Cipralex, Inhibitor, Escitalopram, Escitalopram Oxalate, impairments, inhibit, SSRI, SLC6A4, reuptake, S-enantiomer, selectivity, SERT, SerotoninTransporter, Serotonin Transporter

Compound Identifiers

PubChem CID

146571