Erythromycin cyclocarbonate

SKU: orb1224693

Description

A derivative of Erythromycin that inhibits protein synthesis of bacteria by binding to the 50S ribosome, shows activity against Gram-positive and some Gram-negative microorganisms.

Key Properties

• CAS Number: 55224-05-0
• MW: 759.921
• Purity: >98% (HPLC)
• Formula: C₃₈H₆₅NO₁₄
• SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]4OC(=O)O[C@]14C
• Target: Antibacterial
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  Erythromycin is used in treatment of respiratory, gastrointestinal, and genital tract infections, as well as skin and soft tissue infections. Erythromycin, with its ten chiral centers and two sugar substituents (L-cladinose and D-desosamine), is a good starting point for numerous medicinal chemistry efforts for improvement of its biological profile (better activity, higher stability, and improved bioavailability) since the first generation of macrolides, which had low toxicity and good tolerability, are unstable in acidic media, had low toxicity and good tolerability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Davercin

Quick Database Links

Gene Symbol

Antibacterial