Ercalcitriol

SKU: orb1679020

Description

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is the physiologically active form of vitamin D2. It enhances innate immunity by upregulating antimicrobial peptides like cathelicidin (CAMP) and defensin β-4 (DEFB4), making it a valuable tool for immunology and infectious disease research in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 60133-18-8
• MW: 428.65
• Purity: 99.02% (May vary between batches)
• Formula: C₂₈H₄₄O₃
• SMILES: C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
• Target: Vitamin,Endogenous Metabolite,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM);DMSO:45 mg/mL (104.98 mM)

Bioactivity

• In Vivo:
  Ercalcitriol binds to vitamin D receptor (VDR), a nuclear receptor, activates the interaction between VDR and retinol X receptor (RXR) to form VDR/RXR/ cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ercalcitriol, 1α,25-Dihydroxy Vitamin D2, 1alpha,25-Dihydroxy Vitamin D2, 1a,25-Dihydroxy Vitamin D2, VK2 analog

Compound Identifiers

PubChem CID

9547243