ER-000444793

SKU: orb1308330

Description

ER-000444793

Research Area

Metabolism Research

Key Properties

• CAS Number: 792957-74-5
• MW: 354.4
• Purity: 99.55%
• Formula: C₂₃H₁₈N₂O₂
• SMILES: O=C(Nc1ccccc1Cc1ccccc1)c1cc(=O)[nH]c2ccccc12
• Target: Mitochondrial Metabolism
• Solubility: DMSO:50 mg/mL (141.08 mM)

Bioactivity

• Target IC50:
  mPTP:2.8 μM
• In Vitro:
  ER-000444793 is a small molecule and non-toxic mPTP inhibitor. It also has a mechanism of action independent of CypD inhibition. Both CsA and SfA dose-dependently reduce HTRF signal, showing the displacement of labeled CsA from rhCypD protein (CsA IC50=23 nM and SfA IC50= 5 nM). However, ER-000444793 has no effect up to a concentration of 50 μM, showing be short of displacement of labelled-CsA from rhCypD protein. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. These data display the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mitochondrial Metabolism, MitochondrialMetabolism, Inhibitor, inhibit, mPTP, ER000444793, ER-000444793, ER 000444793

Compound Identifiers

PubChem CID

2547533