Eplerenone

SKU: orb1227029

Description

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors. (In Vitro):Eplerenone inhibits the human mineralocorticoid receptor with IC50 value of 0.081 μM.(In Vivo):Eplerenone (oral, 200 mg/kg/day for 3 months) significantly reduces oxidative stress and atherosclerosis progression in atherosclerotic apolipoprotein edeficient (EO) mice.

Key Properties

• CAS Number: 107724-20-9
• MW: 414.49
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₀O₆
• SMILES: C[C@]12CCC(C=C1C[C@@H](C(OC)=O)[C@@H]3[C@]24[C@@H](C[C@@]5(C)[C@H]3CC[C@@]56CCC(O6)=O)O4)=O
• Target: GR
• Solubility: Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP 30083 | (+)-Eplerenone | Epoxymexrenone | SC-6110 | SC-66110

Quick Database Links

Gene Symbol

GR