Epiroprim

SKU: orb1702301

Description

Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity against Gram-positive pathogens like Staphylococci and Streptococci. It serves as a research tool for studying bacterial folate metabolism and has been utilized in both in vitro and in vivo antimicrobial research models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 73090-70-7
• MW: 353.42
• Formula: C₁₉H₂₃N₅O₂
• SMILES: O(CC)C1=C(C(OCC)=CC(CC=2C(N)=NC(N)=NC2)=C1)N3C=CC=C3
• Target: Others

Bioactivity

• Target IC50:
  DHFR:0.9 μmol
• In Vivo:
  Epiroprim (300 mg/kg/ day for 14 days, given intraperitoneally) was ineffective against mice acutely infected with the RH strain of Toxoplasma Gondii, but when Epiroprim was combined with oral sulfadiazine (375 mg/kg/ day), a 100% survival rate was seen. Epiroprim (100 mg/kg) combined with dapsone can prevent pneumosporosis and toxoplasmosis in rats.
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• In Vitro:
  The 50% inhibitory concentration (IC50) of Epiroprim against Toxoplasma gondii dihydrofolate reductase was 0.9 μmol. Epiroprim has bactericidal effect with a minimum inhibitory activity of 10 mg/L against Mycobacterium leprae.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro-11-8958, Ro11-8958, RO 118958, Ro 11-8958, Epiroprim, Epiroprime

Compound Identifiers

PubChem CID

68916