EOAI3402143

SKU: orb1309700

Description

EOAI3402143

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1699750-95-2
• MW: 503.42
• Purity: 98.09% (May vary between batches)
• Formula: C₂₅H₂₈Cl₂N₄O₃
• SMILES: CCCC(NC(=O)C(=C\c1nc(Cl)ccc1Cl)\C#N)c1ccc(OCCN2CCOCC2)cc1
• Target: DUB
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:75 mg/mL (148.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.97 mM)

Bioactivity

• In Vivo:
  EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice.
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• In Vitro:
  EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice. Usp9x inhibition by EOAI3402143 treatment reduced 3D colony formation in PANC1 and PDX cell lines, induced rapid apoptosis in MIAPACA2 cells, and associated with reduced Mcl-1 and ITCH protein levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DUBs, Deubiquitinase, EOAI 3402143, EOAI3402143, EOAI-3402143, Inhibitor, inhibit, USP9x, USP24, Usp5

Compound Identifiers

PubChem CID

91669215