Entrectinib-d8

SKU: orb3138557

Description

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is the deuterated form of Entrectinib. Entrectinib (NMS-E628) is an orally bioavailable inhibitor that effectively crosses the blood-brain barrier and exhibits central nervous system activity. It targets TrkA/B/C, ROS1, and ALK with IC50 values of 1, 3, 5, 12, and 7 nM, respectively. Entrectinib induces apoptosis and cell cycle arrest in cancer cells, demonstrates antitumor properties, and alleviates bleomycin-induced pulmonary fibrosis in mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2251773-94-9
• MW: 568.69
• Formula: C₃₁H₃₄F₂N₆O₂
• SMILES: N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3C(C(N(C)C(C3([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5
• Target: ROS Kinase,ALK,Autophagy,Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS Kinase,ALK,Autophagy,Trk receptor