Ensaculin

SKU: orb1745210

Description

Ensaculin (Anseculin) is a piperazine-substituted benzopyrone with demonstrated cognitive-enhancing effects in rodent memory models, including passive and conditioned avoidance tests. It exhibits neuroprotective activity against NMDA-induced toxicity and neurotrophic effects in primary rat brain cell cultures, supporting its research application in dementia and neurodegenerative disease studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 155773-59-4
• MW: 452.54
• Purity: 99.81% (May vary between batches)
• Formula: C₂₆H₃₂N₂O₅
• SMILES: CC=1C=2C(=CC(OC)=C(OCCCN3CCN(CC3)C4=C(OC)C=CC=C4)C2)OC(=O)C1C
• Target: iGluR,Dopamine Receptor,Others,Adrenergic Receptor,5-HT Receptor
• Solubility: DMSO:42.6 mg/mL (94.14 mM)

Bioactivity

• Target IC50:
  5-HT1A:8 nM|D4:277 nM|5-HT2:＞100 nM|α:＞100 nM|α1B-adrenoceptor:9.3 nM|D3:27.7 nM|α1A-adrenoceptor:4.7 nM|D2:16.6 nM
• In Vivo:
  Ensaculin (0.1, 1 and 10 mg/kg; i.p.; Wistar rats; 20 min after the onset of glutamate perfusion) significantly antagonized the formation of 2,3-DHBA, to values of 60.5% and 56.7% of control levels, respectively. Ensaculin may be useful in the treatment of neurodegenerative disorders associated with elevated hydroxyl free radicals and excitotoxicity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anseculin, Ensaculin

Compound Identifiers

PubChem CID

208923