Enocitabine

SKU: orb1308334

Description

Enocitabine is a nucleoside analog with antileukemic and antiviral properties, functioning as a DNA replication inhibitor and chain terminator. It is utilized in research for its activity against HCMV and leukemia, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 55726-47-1
• MW: 565.78
• Purity: 98.02%
• Formula: C₃₁H₅₅N₃O₆
• SMILES: CCCCCCCCCCCCCCCCCCCCCC(=O)Nc1ccn([C@@H]2O[C@H](CO)C(O)[C@H]2O)c(=O)n1
• Target: DNA/RNA Synthesis,Virus Protease,HCV Protease,Nucleoside Antimetabolite/Analog
• Solubility: DMSO:2 mg/mL (3.53 mM)

Bioactivity

• In Vitro:
  The combined effects of Pirarubicin and Enocitabine on HeLa S3 human uterine cervix carcinoma and K562 human myelocytic leukemia cells are determined by enhancement of their cytotoxic activities. Enocitabine or etoposide shows synergistic effects on HeLa S3 and K562 cells . In the presence of Enocitabine, triphosphate forms of the nucleoside analogs are detected in the human cytomegalovirus (HCMV)-infected cells, and synthesis of HCMV DNA is strongly suppressed .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CMV, DNA replication, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, Cytomegalovirus, AML, Analog, acute myelogenous leukaemia, NucleosideAntimetabolite, Nucleoside Antimetabolite, Nucleoside Analogue, Nucleoside Antimetabolite/Analog, inhibit, Inhibitor, HCV Protease, HCVProtease, HCMV, Enocitabine, RNASynthesis, RNA Synthesis, Sunrabin

Compound Identifiers

PubChem CID

68022656